kazaa81 - 1-5-2005 at 05:03
Hallo to all,
I have heard about "phenacetin", a derived compound from phenols, but found nothing about synthesis.
Could anyone help me?
Thanks at all for help! 
sparkgap - 1-5-2005 at 05:15
A synthesis of phenacetin? Here's a tip (applicable to all those looking for syntheses of medicinal compounds):
Look for its entry in the Merck Index (any later version should do, or you could download Organikum's 13.1 copy from the FTP). Somewhere in the
entry is usually a reference on how it is/was synthesized, usually an article in a journal or a patent.
Why would you want to make phenacetin?
If you can still find "APC" pills in the nearby apothecary, you can attempt extracting phenacetin from them (although nephrotoxicity
concerns caused a steady decline in distribution and use of those pills).
Otherwise, you could try starting from acetaminophen.
Just my two cents...
sparky (^_^)
P.S. Uncannily enough, one of the reasons why phenacetin works is that the good ol' liver metabolizes it into acetaminophen. 
[Edited on 1-5-2005 by sparkgap]
overseer - 18-6-2005 at 02:56
These three pages from Vogel describe the synthesis.
Attachment: phenacetin.pdf (371kB)
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