Sciencemadness Discussion Board

GABA ethyl ester and GABA questions.

oneoverzero - 1-10-2014 at 13:22

Hello, Hi, I'm new to organic chemistry, and I would synthesize GABA ethyl ester.

My first question I have is, why my GABA is not soluble in water? I have tried two different brands sold in capsules. Why adding a few drops of hydrochloric acid, makes perfectly dissolve in water and ethanol?

My second question is, can I make Fitcher esterifiacion of GABA in absolute alcohol and a few drops of hydrochloric acid to 20%? Or maybe the water would prevent esterification and sulfuric acid is necessary?

My third question is, why can not neutralize the hydrochloric acid with sodium bicarbonate in a solution of ethanol?

Sorry for my bad english and congratulation to many members of this forum have resolved many doubts me just reading your posts