Boba155 - 15-6-2011 at 19:55
Is there a difference in epimers biological effects?
For instance, I have 11β-PGE2. Will it have the same effects in vivo upon injection as normal PGE2?
If not, is there a way to convert an epimer to it's normal configuration? Or is this impossible.
Thanks!
phlogiston - 16-6-2011 at 12:56
In general yes, but for the specific prostaglandins that you mention, I have no idea.
The (dia)stereoisomers of most biologically relevant molecules that are chiral have very different biological effects.
Preparing a specific stereoisomer (be it from another isomer or from other precursors) may be easy or impossible depending on the molecule. What
epimers are you interested in, specifically?
Boba155 - 16-6-2011 at 16:37
I'm actually looking to synthesize the biologically active forms of either PGE2 or PGA2.
I can start from scratch or from their epimers (11beta-PGE2 or 15beta-PGA2).
Any help or guides?