Boba155
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Difference in epimers?
Is there a difference in epimers biological effects?
For instance, I have 11β-PGE2. Will it have the same effects in vivo upon injection as normal PGE2?
If not, is there a way to convert an epimer to it's normal configuration? Or is this impossible.
Thanks!
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phlogiston
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In general yes, but for the specific prostaglandins that you mention, I have no idea.
The (dia)stereoisomers of most biologically relevant molecules that are chiral have very different biological effects.
Preparing a specific stereoisomer (be it from another isomer or from other precursors) may be easy or impossible depending on the molecule. What
epimers are you interested in, specifically?
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"If a rocket goes up, who cares where it comes down, that's not my concern said Wernher von Braun" - Tom Lehrer |
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Boba155
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I'm actually looking to synthesize the biologically active forms of either PGE2 or PGA2.
I can start from scratch or from their epimers (11beta-PGE2 or 15beta-PGA2).
Any help or guides?
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