Today I've decided to start on a big project:
imidazoles!
I plan on starting with the chemicals in my lab to try the Debus–Radziszewski synthesis of imidazole, possibly 2-amino imidazole, and if I'm still
feeling ambitious, 1,4,5 methyl imidazole
current plans:
create nitric acid from nitrates and h2so4
form glyoxal from ethanol and nitric acid
condense with p-formaldehyde and ammonia to get imidazole
2-amino imidazole:
form guanidine from molten urea/ammonium nitrate
condense guanidine with glyoxal
1,4,5 methyl imidazole
acetaldehyde via acid-catalyzed dehydration of ethylene glycol
forming diacetyl from acetone condensation and oxidation
Debus-Radziszewski with ammonia
from there if my yields are good enough and I'm able to recover enough, I might make some ionic liquids
forming diacetyl from acetone condensation and oxidation
I don’t quite understand what kind of approach you mean by that, could you send a picture of the reaction scheme?imidazole - 30-3-2025 at 21:18
the kind where you sketch something wrong and accidentally erase two carbons bnull - 31-3-2025 at 03:38
I thought you were going to do a condensation of formaldehyde with acetone to form MEK and then oxidise MEK to diacetyl by either passing its vapor
over hot vanadium (or phosphorus) pentoxide or oxygen in solution with a zeolite-based catalyst. I can dig out the papers if you want.
But your way seems much better, he he he...chempyre235 - 31-3-2025 at 06:12
Of course, MEK is available OTC in the US. I just saw some at Menard's a couple of weeks ago. Might simplify the process a little bit.
