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Author: Subject: First big goal: OTC total synthesis of imidazole
imidazole
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[*] posted on 28-3-2025 at 10:52
First big goal: OTC total synthesis of imidazole


Today I've decided to start on a big project:
imidazoles!

I plan on starting with the chemicals in my lab to try the Debus–Radziszewski synthesis of imidazole, possibly 2-amino imidazole, and if I'm still feeling ambitious, 1,4,5 methyl imidazole

current plans:
create nitric acid from nitrates and h2so4
form glyoxal from ethanol and nitric acid
condense with p-formaldehyde and ammonia to get imidazole

2-amino imidazole:
form guanidine from molten urea/ammonium nitrate
condense guanidine with glyoxal

1,4,5 methyl imidazole

acetaldehyde via acid-catalyzed dehydration of ethylene glycol
forming diacetyl from acetone condensation and oxidation
Debus-Radziszewski with ammonia

from there if my yields are good enough and I'm able to recover enough, I might make some ionic liquids

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Niklas
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[*] posted on 29-3-2025 at 04:39


Quote: Originally posted by imidazole  

forming diacetyl from acetone condensation and oxidation


I don’t quite understand what kind of approach you mean by that, could you send a picture of the reaction scheme?
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imidazole
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[*] posted on 30-3-2025 at 21:18


the kind where you sketch something wrong and accidentally erase two carbons
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bnull
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[*] posted on 31-3-2025 at 03:38


I thought you were going to do a condensation of formaldehyde with acetone to form MEK and then oxidise MEK to diacetyl by either passing its vapor over hot vanadium (or phosphorus) pentoxide or oxygen in solution with a zeolite-based catalyst. I can dig out the papers if you want.

But your way seems much better, he he he...



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chempyre235
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[*] posted on 31-3-2025 at 06:12


Of course, MEK is available OTC in the US. I just saw some at Menard's a couple of weeks ago. Might simplify the process a little bit.
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