Cyclam

Cyclam

Names
IUPAC name 1,4,8,11-Tetraazacyclotetradecane
Other names 14-crown-4N4
Properties
Chemical formula	C10H24N4
Molar mass	200.330 g/mol
Appearance	While crystalline solid
Density	0.861 g/cm3
Melting point	185–188 °C (365–370 °F; 458–461 K)
Boiling point	321.1 °C (610.0 °F; 594.2 K)
Solubility in water	5 g/100 ml (20 °C)
Solubility	Reacts with acids
Hazards
Safety data sheet	Sigma-Aldrich
Lethal dose or concentration (LD, LC):
LD50 (Median dose)	371 mg/kg (mouse, IP)
Related compounds
Related compounds	Cyclen
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Cyclam or 1,4,8,11-tetraazacyclotetradecane is an organic chemical compound with the formula C₁₀H₂₄N₄. It is an aza-crown ether, an aza analogue of a crown ether.

Properties

Chemical

Cyclam will form coordination complexes with transition metal salts.

Physical

Cyclam is a colorless crystalline solid, slightly soluble in water.

Availability

Cyclam is sold by chemical suppliers and can be bought online.

Preparation

Cyclam can be prepared by the reaction of 1,3-dibromopropane and ethylenediamine:

(CH₂)₃Br₂ + (CH₂)₂(NH₂)₂ → (NHCH₂CH₂NHCH₂CH₂CH₂)₂

Projects

• Metal-cyclam complexes
• Compound collecting

Handling

Safety

There is little available data on the toxicity of cyclam, but, like all amines, it should be handled with care.

Storage

In closed bottles, away from acids.

Disposal

Can be neutralized by destroying it using an oxidizing mixture.