CrossxD
Hazard to Self
Posts: 66
Registered: 6-7-2015
Member Is Offline
Mood: stainless
|
|
andrafinil
hallo
I found this https://www.erowid.org/archive/rhodium/chemistry/adrafinil.m... and I like to try it but I dont have any thiourea and diphenyl methane.
Is possible to make thiourea from calcium cyanamide and hydrogen sulphide? And How I can make diphenyl methane? from phenol and toluene?
Thank you so much  D
|
|
|
careysub
International Hazard
Posts: 1339
Registered: 4-8-2014
Location: Coastal Sage Scrub Biome
Member Is Offline
Mood: Lowest quantum state
|
|
You might look at the modafinil synthesis on the same page using benzhydrol (there is also a thread on this particular synthesis on SM).
Modafinil is generally preferable to adrafinil (which is actually a modafinil pro-drug it is metabolized into modafinil to be effective). It is
somewhat more potent, takes effect faster, does not require that it be taken in an empty stomach, and had fewer adverse side effects.
Benzhydrol can be prepared from benzophenone, with sodium borohydride or zinc dust as reducing agents.
http://www.chemistry.mcmaster.ca/~chem3d3/old-labmanual/3d3e...
http://www.orgsyn.org/demo.aspx?prep=cv1p0090
Attachment: Example_Expt_Writeup.pdf (176kB)
This file has been downloaded 10298 times
Attachment: chem360_lm.pdf (1MB)
This file has been downloaded 925 times
|
|
|
Texium
|
Thread Moved
17-5-2016 at 12:58 |
Metacelsus
International Hazard
Posts: 2539
Registered: 26-12-2012
Location: Boston, MA
Member Is Offline
Mood: Double, double, toil and trouble
|
|
You might be able to extract thiourea from some silver tarnish removers (they contain 5-7% of it; see https://householdproducts.nlm.nih.gov/cgi-bin/household/bran...).
Alternatively, you could buy it on eBay.
[Edited on 5-18-2016 by Metacelsus]
|
|
|
careysub
International Hazard
Posts: 1339
Registered: 4-8-2014
Location: Coastal Sage Scrub Biome
Member Is Offline
Mood: Lowest quantum state
|
|
Thiourea can be obtained in the U.S. also from:
Elemental Scientific LLC: $10.99 for 4 oz
Firefox-FX: $13/lb
Amazon.com: $9/3 oz
|
|
|
CuReUS
National Hazard
Posts: 928
Registered: 9-9-2014
Member Is Offline
Mood: No Mood
|
|
there is another route you could try
1.synthesis of 2-benzhydrylsulfanylacetic acid from benzhydrol and thioglycolic acid
http://pubs.acs.org/doi/abs/10.1021/jm00072a019
2.andrafinil from 2-benzhydrylsulfanyl ethyl acetate
http://www.sciencedirect.com/science/article/pii/S0957416604...
|
|
|
Chemi Pharma
Hazard to Others
Posts: 349
Registered: 5-5-2016
Location: Latin America
Member Is Offline
Mood: Quarantined
|
|
CrossxD,
the better route to Modafinil that's used by the pharmaceutical community:
Benzoquinone --> benzhydrol --> condensation with thioglycolic acid in TFA --> oxidation of the sulphur with hydrogen peroxide in H2SO4
--> fischer ethyl esterification of the acid --> ammonolisys of the ethyl ester to afford the amide.
If you want Andrafinil, at the latest step, instead of ammonolisys, react the ester with an alkaline solution of hydroxylamine.
Study very hard the papers i attached below and for sure you'll be able to sinthesize a few grams, like i did at the university lab.
Attachment: modafinil - complete synthesys.pdf (204kB)
This file has been downloaded 399 times
Attachment: modafinil II.pdf (303kB)
This file has been downloaded 403 times
Attachment: modafinil III.pdf (262kB)
This file has been downloaded 543 times
Attachment: modafinil IV.pdf (237kB)
This file has been downloaded 430 times
[Edited on 19-5-2016 by Chemi Pharma]
[Edited on 19-5-2016 by Chemi Pharma]
[Edited on 19-5-2016 by Chemi Pharma]
|
|
|
CrossxD
Hazard to Self
Posts: 66
Registered: 6-7-2015
Member Is Offline
Mood: stainless
|
|
Thank you I will try but can I moke thioglycolic acid from chlor acetec acid and hydrogen sulphide? Or is there better way do it?
|
|
|
CuReUS
National Hazard
Posts: 928
Registered: 9-9-2014
Member Is Offline
Mood: No Mood
|
|
Quote: Originally posted by CrossxD  | | but can I moke thioglycolic acid from chlor acetec acid and hydrogen sulphide? Or is there better way do it? |
you could make it by decomposing dithioglycolic acid(now don't ask me how to make that  )
http://link.springer.com/article/10.1023/A%3A1022276812235
but I suggest you buy it since its extremely cheap and not watched.
|
|
|
![[*]](images/xpblue/default_icon.gif){kind=icon}
