Sadia Noor
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lithium phenylacetylide
Please somebody give me method for the Preparation of Lithium Phenylacetylide
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clearly_not_atara
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See the preparation in the Prepublication forum:
http://www.sciencemadness.org/talk/viewthread.php?tid=18681
It's always a good idea to check prepub for the compund you're looking for or a similar one before asking here. Be aware that phenylacetylene is not a
precursor for the title compound.
| Quote: | | what would happen if instead of formic acid, formamide was used along with a reducing agent like NaBH3CN or the formamide was itself used to do a one
pot reduction of the enamine formed ? |
It's not quite the same thing but I always thought the direct thermal conversion of allenes to nitrones was pretty cool:
http://pubs.acs.org/doi/suppl/10.1021/ol900292r
I searched for formamide and didn't find much; it seems like hydroamination using simple amines is more common, although interestingly
alpha-phenylethylformamides undergo an annulation with alkynes:
http://pubs.acs.org/doi/abs/10.1021/ja1102037
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CuReUS
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why not ? won't reacting phenylacetylene with LDA or BuLi or even LiNH2 give lithium phenylacetylenide ?
http://www.orgsyn.org/demo.aspx?prep=CV8P0391
| Quote: | | I searched for formamide and didn't find much; |
as I always like to believe and say,just because it hasn't been done before doesn't make it impossible.If someone told me that you could make ketones
from alkynes using only formic acid acid, i wouldn't have believed them.But its true.
| Quote: | | it seems like hydroamination using simple amines is more common |
but most of them if not all ,need a catalyst.
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clearly_not_atara
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By "title compound" I meant phenylacetylcarbinol, not lithium phenylacetylide. Sorry for the misunderstanding.
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Polverone
Now celebrating 21 years of madness
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Thread Moved
12-3-2016 at 14:44 |
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