SnuffStuff
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New Otc way for (new)Arylcyclohexylamines
Hallo guys,
after a lot brain wash and search for search, i've found a new Otc way for the synth of new Pcp and Mxe derivatives and also for normal Pcp i think.
Because i hate grignards and cyanogen compounds was the goal for me to find an Easy and Otc'ish to the lovly Arylcyclohexylamines.
Way for Pcp derivatives:
1.Preparation of Hydroxylamine from Nitromethane and aq.Hcl.
2.Benzaldoxime from Hydroxylamine and Benzaldehyd.
3.Phenylnitromethane by Peracetic acid oxidation of the Bz-oxim.
4.Phenylnitromethane condensation with gluteral to form 1-Nitro-1-Phenylcyclohexane-2,6-diol.
So thats the beginnig, at this moment gives 4+ possible ways to go for the different compound.
(1)* Not so Otc: (1.1) Dehydration with phathalic anhydride.
(1.2)Electrolytic Reduction of the double-bonds and the nitro group to 1-phenylcyclohexylamine.
(1.3)Reductive alkylation with Glutaral and Nabh4 to form Phencyclidine.
(2)* (2.1)Ether cyclisation of 1-Nitro-1-Phenylcyclohexane-2,6-diol to i cant find the right Name sorry.
(2.2)Reduction with Zinc or Al/Hg or ectrolytic.
(2.3)Reductive Alkylation to 2,3-?-Phencyclidine
(3.0)* So yet a possible Mxe/Pcp derivate.
[Possible to Brominate the Benzaldehyde in the beginning and react with Magnesium Methoxide to give 3-Methoxybenzaldehyde]
(3.1)Reduction either by zinc or Al/Hg or electrolytic.
(3.2)Reductive alkylation with Glutaral oder Acetaldehyde and Nabh4.
(3.3)Mild oxidation of the 2 alcohol groups to give (with 3-Meo-Bnz and acetal) 3-Meo-2,6-dioxo-Pce an Mxe derivativa without stereocenter i think to
give hopefully an very active compound.
So guys what are you think about it? All is Otc were I live, only Phathalic anhydride must be orderd by the chem supplie.
Have a nice Weekend and much fun with this shit 
Kind regards StuffSnuffer
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Nicodem
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Thread Moved
1-8-2015 at 13:20 |
skip
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Too much work for a not so kind compound that is undesired by most. No one cares about that crap anymore.
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SnuffStuff
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Thx for the fast reply,
There's one another possibility of Methoxetamine/Pcp Analoges.
The carbonyl group on the cyclohexane ring may changed to a Phenyl group like the b-keto- b-phenyl- Methamphetamine.
This is easy done by the cyclohexanone enolate.
On the b-carbon of Amphetamines most aromatic groups are usefull substitutes.
What do ya think about it?
Sry but I'm sure that the Arylcyclohexylamines can much more than this.
And many People here like Pcp and Mxe a very much.
Shit that nobody here work for a Pharma industy with handling of such substanzes. =(
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AvBaeyer
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I worked many years in the pharma industry and know much about what you are blathering about but I wouldn't give you the time of day regarding what
you are trying to do. Just not interesting.
AvB
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byko3y
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Man, you should really start performing experiments by yourself, because the propose routes you propose most likely will not work. And you'd better
provide some references before you make propositions, and obviously you don't have references because those reactions do not work.
I'm talking about double nitroaldol condensation, electrolytic reduction of complex nitroalcohol (we don't even know whether this compound is stable).
"Possible to Brominate the Benzaldehyde in the beginning" - no;
"react with Magnesium Methoxide to give 3-Methoxybenzaldehyde" - no;
"i think to give hopefully an very active compound" - most likely no.
[Edited on 9-8-2015 by byko3y]
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