I don't really know anything about a-nitro carboxylic acids but doubt the amine and acid would condense. IFAIK that only happens intramolecularly.
I based my activation logic on the HVZ reaction.Normal carboxylic acids require catalytic PBr3
but nitro-acids can be brominated directly.Also,its a well known fact that adding electron withdrawing groups increases the acidity.More acidity =
more reactivity.
Quote:
some peptide synthesis would be more successful.
peptide coupling reagents were proposed and disposed of way
up this thread due to non-OTC concerns
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