Db33
Hazard to Others
Posts: 206
Registered: 25-11-2016
Member Is Offline
Mood: No Mood
|
|
Hand sanitizer ratio
Being such a difficult time for everyone, i knew this would be the place to get the help i need for this ratio. I want to make some hospital grade
hand sanitizer because my local establishments (like everyone elses) has basically been sold out for months..
Anyways the formula i got for this sanitizer is
by % weight/weight,
1. 70% - pure Isopropanol, or Ethanol
2. 5% - 1,3 - Propanediol
3. 1.2% - Sepimax Zen
4. fill to 100% - Distilled Water
5. q.s. - pH adjustor.
Im pretty sure i understand the basics but, can someone with a chemistry or math degree tell me in mLs and grams what amounts i would need for each?
The Sepimax Zen is a powder. The Isopropanol is 99.9, but ill say close to pure. The formula says add the water to fill to 100%.
If i wanted to make 1 liter lets say, what amounts would i use?
Thanks for the help guys, and gals.
|
|
|
numos
Hazard to Others
Posts: 269
Registered: 22-2-2014
Location: Pasadena
Member Is Offline
Mood: No Mood
|
|
Just multiply everything by final amount
If you want 1kg
1 kg x .7 = 700 g
1 kg x .05 = 50 g
1 kg x .012 = 12 g
etc...
|
|
|
Db33
Hazard to Others
Posts: 206
Registered: 25-11-2016
Member Is Offline
Mood: No Mood
|
|
so for liquids, just weigh them the same as a solid? put a beaker on scale and then weigh it from there?
Also, would the water be 238g to make it 100%?
|
|
|
B(a)P
International Hazard
Posts: 1139
Registered: 29-9-2019
Member Is Offline
Mood: Festive
|
|
Or you could simply and go with the WHO recommendation.
https://www.ncbi.nlm.nih.gov/books/NBK144054/
|
|
|
j_sum1
Administrator
Posts: 6320
Registered: 4-10-2014
Location: At home
Member Is Offline
Mood: Most of the ducks are in a row
|
|
Most recipes I have seen contain glycerine to slow evaporation of the alcohol via hydrogen bonding.
|
|
|
Bedlasky
International Hazard
Posts: 1239
Registered: 15-4-2019
Location: Period 5, group 6
Member Is Offline
Mood: Volatile
|
|
Glycerol is also for hydratation of the skin. Isopropyl alcohol and ethanol dries the skin.
|
|
|
Db33
Hazard to Others
Posts: 206
Registered: 25-11-2016
Member Is Offline
Mood: No Mood
|
|
the Propanediol is used in place of the glycerine, i have both but i am going to try it with the propanediol.
I also asked the maker of the formula if they knew what ph adjuster to use. Im not sure if it turns out basic or acidic. But im thinking either acetic
or citric acid if it needs to be more acidic and sodium carbonate if it needs to be more basic.
|
|
|
unionised
International Hazard
Posts: 5126
Registered: 1-11-2003
Location: UK
Member Is Offline
Mood: No Mood
|
|
Quote: Originally posted by Db33  |
I also asked the maker of the formula if they knew what ph adjuster to use. Im not sure if it turns out basic or acidic. But im thinking either acetic
or citric acid if it needs to be more acidic and sodium carbonate if it needs to be more basic. |
Those seem reasonable choices.
Also, there's a pandemic going on; none of the ingredients has a pH far from neutral*, so it should hardly matter.
*
Yes, I know, the pH of, for example isopropanol is pretty much meaningless. The point is that none of the ingredients should overcome the buffering
ability of the skin.
|
|
|
Bedlasky
International Hazard
Posts: 1239
Registered: 15-4-2019
Location: Period 5, group 6
Member Is Offline
Mood: Volatile
|
|
Db33:
In work we make hand sanitizer by WHO recommendation and there isn't any pH adjuster - so I think that it isn't necessary.
I have hand sanitizer from farmacy and it contains water, isopropyl alcohol, some blue colorant and benzyl-C12-C16-alkyldimethylammonium chlorides as
active substance. Also without any pH adjuster.
But your choice of pH adjusters seems reasonable.
|
|
|
S.C. Wack
bibliomaster
Posts: 2419
Registered: 7-5-2004
Location: Cornworld, Central USA
Member Is Offline
Mood: Enhanced
|
|
BTW IIRC according to the USP and FDA , WHO now says IPA is more effective with half the glycerin that is in the formula there...or something...in any
case, in the current recommendations the 80% EtOH retains the original amount and the 75% IPA is half, 0.725%.
|
|
|
Herr Haber
International Hazard
Posts: 1236
Registered: 29-1-2016
Member Is Offline
Mood: No Mood
|
|
| Quote: Originally posted by Db33 | the Propanediol is used in place of the glycerine, i have both but i am going to try it with the propanediol.
I also asked the maker of the formula if they knew what ph adjuster to use. Im not sure if it turns out basic or acidic. But im thinking either acetic
or citric acid if it needs to be more acidic and sodium carbonate if it needs to be more basic. |
The reason for the PH adjuster might also be that the polymer you have in your recipe might need a slightly acidic PH.
Carbomer 940 which could be used for the same effect needs about PH 6
The spirit of adventure was upon me. Having nitric acid and copper, I had only to learn what the words 'act upon' meant. - Ira Remsen
|
|
|
Chemorg42
Hazard to Others
Posts: 103
Registered: 12-11-2019
Member Is Offline
Mood: Concentrated
|
|
This seems to be the place to discuss pandemic sanitizer recipes, so here it goes:
3 parts 99% 2Propanol to 1 part Glycerol, add several drops of a fragrance of your choice (optional)
This is the formulation I used, nothing fancy but it seemed to work. I just took the (roughly) 70% alcohol number and diluted the nearly pure
Isopropanol down to that concentration with glycerol.
Seems to be similar to the general formula here.
Thoughts?, Suggestions?, Criticisms?
Anyone who is not shocked by quantum theory has not understood a single word. (attributed to Niels Bohr)
I think I can safely say that nobody understands quantum mechanics. (Richard Feynman)
|
|
|
imcool
Harmless
Posts: 3
Registered: 13-4-2020
Member Is Offline
|
|
| Quote: Originally posted by Chemorg42 | This seems to be the place to discuss pandemic sanitizer recipes, so here it goes:
3 parts 99% 2Propanol to 1 part Glycerol, add several drops of a fragrance of your choice (optional)
This is the formulation I used, nothing fancy but it seemed to work. I just took the (roughly) 70% alcohol number and diluted the nearly pure
Isopropanol down to that concentration with glycerol.
Seems to be similar to the general formula here.
Thoughts?, Suggestions?, Criticisms? |
And i didnt even use Glycerol, i only used 70% alcohol and water
|
|
|
Chemorg42
Hazard to Others
Posts: 103
Registered: 12-11-2019
Member Is Offline
Mood: Concentrated
|
|
Water does work to replace Glycerol (I made a batch myself to use as a disinfectant spray), but I find that the Glycerol makes the sanitizer easier to
rub into the skin.
Anyone who is not shocked by quantum theory has not understood a single word. (attributed to Niels Bohr)
I think I can safely say that nobody understands quantum mechanics. (Richard Feynman)
|
|
|
jamit
Hazard to Others
Posts: 375
Registered: 18-6-2010
Location: Midwest USA
Member Is Offline
Mood: No Mood
|
|
I've been researching and making hand sanitizer for over 2 months, before the lockdown in the US. The best gelling agent or thickener is carbomer,
period! There's a reason why every manufacturer of hand sanitizer are using carbomer, becuase it is the most compatible with alcoholic gel.
Currently it is almost impossible to find carbomer, at least, not without paying 5x as much as normal. Most of the carbomer in the world is made
by... you guessed it... China.
I've tried sepimax zen, but it not as effective. Yes, it is alcohol tolerant over 70% but somehow there's a strange smell I don't like from mixing
it with alcohol. I've also tried aristoflex, hydrooxyethylcellulose, zanthan gum, and even sodium polyacrylate. The latter 2 is too sticky and is
not very alcohol tolerant at higher concentration. It is doable but not preferred.
To make a hospital/commerical grade hand sanitizer, the first thing is to hydrate the gelling agent well. then add the alcohol (you need at least 70%
total volume of alcohol) into the gelling agent slowly with stirring and in small increments. Add some glycerin and maybe even propylene glycol and
then some fragrance and you're done.
My personal formula is the following:
25ml of 0.5% carbomer mucillage (using distilled water and adding TEA to thicken -- note, carbomer will not thicken until it reaches a pH of between
6-7 -- you can also use a dilute NaOH solution, but not preferred)
70ml of 95% ethanol or 99% isopropanol
1ml of glyerin
2ml of PEG
1ml of fragrance
1ml of isopropyl mystrate
If you want a professional looking product, you need to use an overhead mixer. hand blender will create small pockets of air bubble, known as
fisheyes. But that's my personal preference. Good luck.
[Edited on 14-4-2020 by jamit]
[Edited on 14-4-2020 by jamit]
[Edited on 14-4-2020 by jamit]
|
|
|
ShotBored
Hazard to Others
Posts: 124
Registered: 19-5-2017
Location: Germany
Member Is Offline
Mood: No Mood
|
|
I've been messing with this a little bit too and found that a mix of the following yields a similar product to commercial hand sanitizers:
75 mL 99% IPA
19 mL DI/RO Water
2.7 mL 3% H2O2 in DI Water
1-2 mL Caprylyl Glycol, glycerine, or a "Moisture Complex" i get from a cosmetics supplier that contains the following: Sodium PCA, Glucose, Urea,
Glutamic Acid, Lysine, Allantoin, Lactic Acid, Water, Glycerin.
The moisture complex can be pretty expensive since its about $400/5kg, however at 1-2% in solution it's cost can be evened out a little bit. Hope this
helps!
|
|
|
ShotBored
Hazard to Others
Posts: 124
Registered: 19-5-2017
Location: Germany
Member Is Offline
Mood: No Mood
|
|
As for a gelling agent, I've found that Hydroxypropyl Methylcellulose compounds like Methocel 311 seem to gel IPA and water mixes quite well. This
compound is much more difficult to get though. For now I settle with run-of-the-mill 100% Aloe Gel from supermarket to get a little more gelling out
of it haha
|
|
|
![[*]](images/xpblue/default_icon.gif){kind=icon}
