Difference between revisions of "Delépine reaction"
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==Mechanism== | ==Mechanism== | ||
The benzyl or alkyl halides react with [[hexamine]], each time just alkylating one nitrogen atom, forming a quaternary ammonium salt. The ammonium salt is refluxed in a concentrated solution of [[ethanol]] and [[hydrochloric acid]], where the quaternary ammonium salt is converted to the primary amine together with [[formaldehyde]] (as the acetal with ethanol) and [[ammonium chloride]]. | The benzyl or alkyl halides react with [[hexamine]], each time just alkylating one nitrogen atom, forming a quaternary ammonium salt. The ammonium salt is refluxed in a concentrated solution of [[ethanol]] and [[hydrochloric acid]], where the quaternary ammonium salt is converted to the primary amine together with [[formaldehyde]] (as the acetal with ethanol) and [[ammonium chloride]]. | ||
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| + | ==Procedure== | ||
| + | To be added | ||
==Projects== | ==Projects== | ||
Latest revision as of 20:40, 28 January 2019
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The Delépine reaction (often, but incorrectly written Delepine reaction) is an organic synthesis of primary amines using hexamine.
Contents
Mechanism
The benzyl or alkyl halides react with hexamine, each time just alkylating one nitrogen atom, forming a quaternary ammonium salt. The ammonium salt is refluxed in a concentrated solution of ethanol and hydrochloric acid, where the quaternary ammonium salt is converted to the primary amine together with formaldehyde (as the acetal with ethanol) and ammonium chloride.
Procedure
To be added
Projects
- Prepare aldehydes from organic halides
