EvlRenne
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"Friendly" synthesis of Benzyl Dimethyl Carbinol
Dear all,
chemistry was always the point of interest of mine, I wanted to do some organic synthesis, I was searching in the web for "friendly" route to
synthesis Benzyl Dimethyl Carbinol (CAS 100-86-7).
I can buy it in China, but price for the delivery is ridiculous and concern about quality.
I want to do it by myself, not only because of price, but curiosity.
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CuReUS
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just do a grignard reaction between benzyl bromide and acetone
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fusso
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I think this could be a candidate for the tert alcohol catalyst in making Na.
[Edited on 06/10/18 by fusso]
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EvlRenne
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I was thinking about following:
C7H7Cl + Mg + Et2O(Anh) + C3H6O(Anh) + NH4Cl and dry it over K2CO3.
Any suggestion?
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Tsjerk
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I would call a grignard "friendly" quite the opposite
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EvlRenne
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I agree, I think I will not be able even start it
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fusso
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Why you want a "friendly" synthesis? How do you define friendly?
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EvlRenne
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Friendly - synthesis which is not require some high-end lab equipment, very complicated steps with special conditions (like hight pressure, hight
temp. and so on), and working with dangerous, but not deadly chemicals.
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fusso
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Quote: Originally posted by EvlRenne  | I was thinking about following:
C7H7Cl + Mg + Et2O(Anh) + C3H6O(Anh) + NH4Cl and dry it over K2CO3.
Any suggestion? |
Then I think that's friendly enough?
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Metacelsus
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What about reacting phenyl-2-propanone with dimethylzinc?
More seriously, the Barbier reaction might be an option. (Benzyl bromide + zinc powder + acetone)
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Tsjerk
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Friendly also includes doable for a beginner, have you ever done a grignard?
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CuReUS
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Yes,that's
a much better idea 
I had heard about the barbier reaction but I didn't know you could do it with Mg or Zn too 
I think you could use benzyl chloride as well
using Mg -https://gallica.bnf.fr/ark:/12148/bpt6k30841/f111.pleinepage...
using Zn -https://www.organic-chemistry.org/abstracts/lit1/029.shtm
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