Radium212
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L Lysine hydrochloride to lysine
Anyone know how one might convert L lysine hydrochloride to lysine? Perhaps reacting with sodium hydroxide to produce sodium chloride and lysine?
Might this work?
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Melgar
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Water solubility is 1.5 kg per liter, which makes that plan prohibitive. Ion exchange resin columns are often used to separate amino acids like this,
but I don't have any experience doing it myself.
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EilOr
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Lysine*HCl is 1.5kg/l, isoelectric lysine 300g/L so in water should work if you're working in concentrated solutions, I don't see why it shouldn't
work using equimolar amounts of NaOH to saturated lysine*HCl solution, though it's not the route I would recommend, as it's lossy unless you're doing
many hours of workup&recristalliation
EtOH or better MeOH might be a much better alternative to water as NaOH is solouble, Lysine*HCl should be well solouble (741g/l in MeOH, 180g/l in 99%
EtOH), Lysine should be quite well solouble aswell, while NaCl isnt (~1.3% in pure MeOH, in EtOH even much less)
So using equimolar masses of NaOH and Lysine*HCl should yield prcp. of NaCl and keep lysine in the alcohol
[Edited on 17-12-2017 by EilOr]
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Radium212
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Quote: Originally posted by EilOr  | Lysine*HCl is 1.5kg/l, isoelectric lysine 300g/L so in water should work if you're working in concentrated solutions, I don't see why it shouldn't
work using equimolar amounts of NaOH to saturated lysine*HCl solution, though it's not the route I would recommend, as it's lossy unless you're doing
many hours of workup&recristalliation
EtOH or better MeOH might be a much better alternative to water as NaOH is solouble, Lysine*HCl should be well solouble (741g/l in MeOH, 180g/l in 99%
EtOH), Lysine should be quite well solouble aswell, while NaCl isnt (~1.3% in pure MeOH, in EtOH even much less)
So using equimolar masses of NaOH and Lysine*HCl should yield prcp. of NaCl and keep lysine in the alcohol
[Edited on 17-12-2017 by EilOr] |
I was thinking along those lines, thanks!
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