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gmiguel
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[*] posted on 13-5-2017 at 12:31
3-n-ethylamino-p-cresol

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gmiguel
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[*] posted on 13-5-2017 at 12:36


I'm interested in synthesis of the above molecule. The classic synthesis involves caustic fusion which creates considerable waste. I know this subject was discussed on this discussion board previously.

I'm interested in any new ideas. Could an aryl sulfotransferase enzyme work?

Comments please.


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[*] posted on 14-5-2017 at 01:39


1.FC acylation of toluene - http://pubs.acs.org/doi/suppl/10.1021/ja8026899/suppl_file/j...
2.nitration of 4-methylacetophenone - http://pubs.acs.org/doi/abs/10.1021/ja1047736
3.One pot baever villager oxidation/hydrolysis on 4-methyl,3-nitroacetophenone -
http://www.ingentaconnect.com/contentone/stl/jcr/2000/000020...
4.reduction of 4-methyl,3-nitrophenol - http://www.sciencedirect.com/science/article/pii/S0960894X10...
5.ethylation of 4-methyl,3-aminophenol - http://onlinelibrary.wiley.com/doi/10.1002/jhet.5570260509/f...

The phenol can also be deprotected after the ethylation.(it might get simultanously deprotected during the ethylation :D)

4-methyl,3-aminophenol.png - 6kB
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