smartgene1
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carboxylic acid and thionyl chloride question
when you react thionyl chloride with a carboxylic acid can it react at room temperature or does it got to be heated to produce the desire acid
chloride, is the reaction exothermic meaning it produce enough heat by it self to drive the reaction forward
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zed
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Find a relevant procedure, for the acid you are try to convert, and follow that procedure....Exactly.
Keep in mind, if you actually intend to run this reaction, that Thionyl Chloride is more-or-less a war-gas. It, or its breakdown products....... can
tear through your lungs like a rampaging Roto-Rooter.
Oh, there I go again, making wild promises.
Now, I have to refresh myself on the specifics, regarding Thionyl Choride.
Just in case I'm wrong.
Yup! It is pretty much, the way I remembered it.
https://en.wikipedia.org/wiki/Thionyl_chloride
While we are on the subject: one of the guys has written up a procedure, for producing Acid Chlorides, from Acids, by treating them with HCl gas, in
the presence of acetonitrile.
Oh, Dammit! I did it again. Now, I've gotta go review the procedure.
https://www.youtube.com/watch?v=ExDI9KUW-9Q
OK, if you are acting on an inexpensive substrate. However, on the other hand, if you are trying to produce your Acyl-Chloride with a wildly
expensive starting acid.....Phosphorus OxyChloride, might be a better reagent to consider.
[Edited on 25-11-2016 by zed]
[Edited on 25-11-2016 by zed]
[Edited on 25-11-2016 by zed]
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CuReUS
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why not just use good old TCT ? http://chemistry.mdma.ch/hiveboard/novel/000372508.html
[Edited on 26-11-2016 by CuReUS]
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smartgene1
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I just want to know if the reaction can be preform at room temperature using thionyl chloride and a carboxylic acid to form a acid chloride
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zed
International Hazard
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In that case..... maybe. Look up the conversion of the acid you are interested in, and see how it was done.
Too many acids out there to make a blanket statement. Some might be difficult to convert... requiring some warming. Many, might require cooling to
0-C., to quell the violence of the reaction.
[Edited on 28-11-2016 by zed]
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