lalalympo
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synthesis of acetophenone
Hello,
this is my first topic on this forum, I'm a bit of a newbie when it comes chemistry but I'm eager to learn.
So I want to synthesize some acetophenone, the stuff pretty much impossible to get where I live.
I've read about Fiedel-Crafts acylation on some forums but not enough to start to preform this reaction.
I want to dry-distill calcium acetate and calcium benzoate, since it seems the easiest. Could I just dump the two in a RBF? Or does it need a
catalyst? If anyone knows how to preform this reaction or has done it I'd be happy to hear about it.
If you have a potentially easier way of making acetophenone (I want to stay away from benzene) you can also tell me
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Nicodem
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Thread Moved
5-9-2016 at 09:59 |
RocksInHead
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From what I've heard an easy way to make it is by reacting acetyl chloride and benzene over an aluminium chloride catalyst.
http://www.prepchem.com/synthesis-of-acetophenone/
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Metacelsus
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That's easy only if you have acetyl chloride and benzene. Also note that the OP wants to avoid using benzene.
The same PrepChem page details a synthesis from calcium benzoate and acetate, which is what the OP requested.
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Dank
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Wacker oxidation of styrene is an option as well. Chemplayer made a video on the calcium acetate/calcium benzoate method but yields were abysmal
IIRC.
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CuReUS
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another method from styrene - http://www.sciencemadness.org/talk/viewthread.php?tid=66322
you could also do a grignard reaction between benzonitrile (made from benzoic acid using urea + sulphamic acid) and MeMgBr
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RocksInHead
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Quote: Originally posted by Metacelsus  | That's easy only if you have acetyl chloride and benzene. Also note that the OP wants to avoid using benzene.
The same PrepChem page details a synthesis from calcium benzoate and acetate, which is what the OP requested.
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Oh, sorry. If I would have read down a little lower then I would have seen it, but I was in a rush anyway. Oh well.
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