bdestrad
Harmless
Posts: 1
Registered: 28-3-2016
Member Is Offline
Mood: No Mood
|
|
Et3N-MeCN in E2 RXN
Is Et3N in acetonitrile (pKa 18.70) sufficient to facilitate an E2 reaction with 1-bromo-4-phenylbutane? Any thoughts on optimization with only these
reagents?
|
|
|
clearly_not_atara
International Hazard
Posts: 2788
Registered: 3-11-2013
Member Is Offline
Mood: Big
|
|
I think the reaction product is 4-phenylbutyltriethylammonium bromide. Consider (Me3Si)2NLi, although in any variant of this reaction, over-alkylation
may be a concern. Using acetonitrile as the solvent may cause self-condensation.
|
|
|
Nicodem
|
Thread Moved
29-3-2016 at 06:35 |
![[*]](images/xpblue/default_icon.gif){kind=icon}
