bdestrad
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Et3N-MeCN in E2 RXN
Is Et3N in acetonitrile (pKa 18.70) sufficient to facilitate an E2 reaction with 1-bromo-4-phenylbutane? Any thoughts on optimization with only these
reagents?
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clearly_not_atara
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I think the reaction product is 4-phenylbutyltriethylammonium bromide. Consider (Me3Si)2NLi, although in any variant of this reaction, over-alkylation
may be a concern. Using acetonitrile as the solvent may cause self-condensation.
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Nicodem
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Thread Moved
29-3-2016 at 06:35 |
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