synthesis of 4-fluorophenyl-2-nitropropene with methylammonium acetate catalyst
1 eq. 4-fluorobenzaldehyde was gently refluxed with 10 mol% eq. of methylammonium acetate, 1.2 eq. of nitroethane and 20 wt.% IPA as solvent for 8
hours, obtaining an amber solution, which upon cooling yields very pure crystal platelets of 4-fluorophenyl-2-nitropropene (88%), 110g out of
100g 4-fluorobenzaldehyde. the latter can be used without further purification because the catalyst is just so clean and produces hardly any
polymer in contrast to the dirty n-butylamine.
yields with plain benzaldehyde (6hrs reflux in IPA): 85%
yield with piperonal (1.5hrs reflux in IPA): 72%
[Edited on 23-1-2006 by stoichiometric_steve]
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