isiahmajor
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possible alternative synthesis of 2,5-dimethoxy-4benzaldehyde
Hi to Everybody and a special hug to nicodem old master at the hive's,
i'm new here, i've a question : in your opinion does exist an alternative way less carcinogenic than the classic formylation with the famigerate
dichloromethyl methyl ether of the benzene ,to obtain the target compound 2,5-dimethoxy-4-ethylbenzaldehyde?
i've used really carefully the UTFSE but with no results
thank's in advance to help me.
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turd
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I suppose the classic Vilsmeier–Haack is out of the question due to alleged difficulties in acquiring POCl3?
Possibly from 1,4-dimethoxy-2-ethyl benzene: https://www.sciencemadness.org/whisper/viewthread.php?tid=11...
If you somehow manage to get 3-ethyl-4-methoxy-phenol, this is very strongly recommended: https://www.sciencemadness.org/whisper/viewthread.php?tid=10...
I guess this should be quite regioselective?
Also maybe Grignard with DMF and bromobenzene?
| Quote: | | i've used really carefully the UTFSE |
Ah - an employee of the department of redundancy department.
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UnintentionalChaos
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Quote: Originally posted by turd  |
| Quote: | | i've used really carefully the UTFSE |
Ah - an employee of the department of redundancy department. |
He doesn't work for me! That man is an impostor!
We need to sticky instructions on how to use google to search the site. Just use site:sciencemadness.org as a search term and it will filter results
to only those that come from this site.
Not that anyone would read it anyway. Such is the nature of forums, I suppose.
Department of Redundancy Department - Now with paperwork!
'In organic synthesis, we call decomposition products "crap", however this is not a IUPAC approved nomenclature.' -Nicodem
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smuv
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Dichloromethyl methyl ether is much less carcinogenic than chloromethyl methyl ether, really it's not too bad. Also I recommend using TiCl4 instead
of SnCl4.
"Titanium tetrachloride…You sly temptress." --Walter Bishop
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