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Author: Subject: 2-chloroacridin-9(10H)-one synthesis
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[*] posted on 16-7-2024 at 00:53
2-chloroacridin-9(10H)-one synthesis

I wondered if this reaction could work in acid.

2-Amino-5-chlorobenzophenone
[719-59-5]

2-chloroacridin-9(10H)-one
[7497-52-1]

The precursor is widely available and the product is used to make clomacran (Devryl).

I saw a similar reaction occuring for Botiacrine synthesis except there it was a tertiary alcohol that is prone to carbocation formation via elimination of water.

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