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Author: Subject: Synthesis of N-methylimidazole
Triflic Acid
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[*] posted on 15-3-2021 at 16:11
Synthesis of N-methylimidazole


I have imidazole, and am going to make N-methylimidazole by reacting it with MeI and then NaOH. What solvent should I use for this reaction?
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Texium
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[*] posted on 15-3-2021 at 16:21


DCM should work well.



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Triflic Acid
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[*] posted on 15-3-2021 at 17:28


Just out of curiosity, did you find that in a prep? If so, could you give a link or something?
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[*] posted on 16-3-2021 at 01:31


I would try water or methyl alcohol first.
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[*] posted on 16-3-2021 at 07:21


Quote: Originally posted by Triflic Acid  
Just out of curiosity, did you find that in a prep? If so, could you give a link or something?
No, just my intuition.
Quote: Originally posted by Boffis  
I would try water or methyl alcohol first.
I don’t think water would be great considering it will react with the methyl iodide and it’s annoying to evaporate. Methanol sounds good though.



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