chemist1243
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Organic Nitrites?
I cant find a damn thing about alkyl nitrites other than that about their biological activity.
I don’t condone spoonfeeding but I really don’t think it applies in my situation because I’ve looked far and wide. The SM library doesn’t have
anything, all research papers only talk about their biological activity/toxicity, and there are almost no references to the use of organic nitrites as
a reactant/precursor in organic synthesis.
All I’m able to assume based on the info I have is that they aren’t very stable.
I would like to know:
How good of a leaving group is the nitrite group?
How are organic nitrites formed(reaction mechanism)?
Are there any reactions that they are used in?(NOT the victor Meyer synthesis, that is INORGANIC nitrite SALTS - not compounds)
I honestly don’t see that much potential in organic nitrites. Maybe if you switched up the victor Mayer synthesis and reacted and alkyl
nitrite with an iodide salt something would happen, but I don’t see any reason to reinventing the wheel.
I have to order more sodium nitrite, so I can’t actually do any experiments atm, but that is my hope for the future. in the meantime, I’d like to
get some useful reference material. If anyone knows more about organic nitrites than me, I’d really appreciate if you would drop what you know
somewhere in this topic.
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arkoma
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i occasionally whip up a dab of ethyl nitrite (strictly for research purposes LMAO), and no, it does not keep well. But, I don't bother with the
fridge, dark bottle etc.
Get my nitrite from Duda Diesel.
"We believe the knowledge and cultural heritage of mankind should be accessible to all people around the world, regardless of their wealth, social
status, nationality, citizenship, etc" z-lib
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Corrosive Joeseph
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http://www.orgsyn.org/demo.aspx?prep=CV2P0363
/CJ
Being well adjusted to a sick society is no measure of one's mental health
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Chemi Pharma
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Preparation of sodium azide from n-butyl nitrite and hydrazine hydrate
Forty to forty-three grams of sodium hydroxide are dissolved in 500 ml of absolute ethyl alcohol by warming. The solution is cooled and either
filtered through a sintered glass funnel or decanted to remove insoluble impurities. To the clear filtrate in a one-liter flask fitted with a reflux
condenser (a ground-glass type is preferable) are added 60 g of 85 % hydrazine hydrate. The mixture is warmed gently on a steam bath and then 15 g of
freshly distilled n-butyl nitrite are added through the condenser. The steam bath is removed and then 110 g more of n-butyl nitrite are added as
before at such a rate that spontaneous refluxing is maintained. The sodium azide precipitates during the procedure. To ensure completion of the
reaction the flask and contents are heated 15-30 minutes after the addition. After cooling in ice, the sodium azide is suction-filtered and washed,
first with four 25 ml portions of ice-cold absolute alcohol, then with two similar volumes of ether. The white salt is dried in warm air yielding
50-55 g of sodium azide.
Inorganic laboratory preparations, by G. G. Schlessinger, 28-29, 1962
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Boffis
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Preparation of dimethylglyoxine from butanone and butyl nitrite then hydroxylammonium chloride
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