xwinorb
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N-methyl isopropylamine synthesis
I have just looked more carefully at the synthesis of this substance, and I have some concerns. The synthesis I am refering to is the one in the
Rhodium page.
Two steps, first forming the trazine, then reducing it with zinc and HCl.
The triazine seems to be ( I hope I had figured it out correctly ) a six ring of alternating C and N atoms. To each N atom one isopropyl radical is
attached, and to each carbon atom two OH ( ? ) are also attached.
I have two questions :
1 ) Does the reduction step yields mostly N-methyl isopropylamine ?
2) I have seen this synthesis in another thread here under the name of "worst stench". This worries me also, could someone who knows more please
comment on that.
Right now I don't have any practical interest in this synthesis, just curious about it.
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mnick12
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While I have not had any expirience with N-methylisopropylamine most amines tend to have a fishy "dead meat" smell, so if I were going to make any I
would make sure to keep it as a salt and not the freebase.
Oh also what is N-methylisopropylamine used for anyway, alkylations?
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xwinorb
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Both methyl isopropylamine and diisopropylamine are used in the synthesis of 4 and 5 substituted tryptamines.
Me and many others like the 4's best, but unhappily main precursors like indole are a difficult aquisition and the 4 substituted T's are sensitive to
moisture, air and I guess also extreme reaction conditions.
I don't think I have the knowledge, experience or resources to make it, I am just curious about it.
I don't like the triazine way, I was just trying to confirm there might be problems with this method or not, just my tentative impression.
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