Yttrium2
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Phenylacetylcarbinol. - how's it made?
So I go to Wikipedia to see how pseudoephedrine is made, it says it's made by l pac. But how is l pac made?
I read yeast ferments dextrose in presence of pyruvate decarboxylase enzyme and then benzaldehyde is added.
Why do I feel like something is left out?
I don't understand the chemistry behind this.
It doesn't seem as clear cut as other chemical reactions, from what I understand, and I know little about chemistry but I can generally follow the
pathways off by anecdote and come to some sort of conclusion about whether or not the schema will work.
Can someone go into a bit of detail about what is pyruvate decarboxylase, dextrose, benzaldehyde, how long have these chemicals been in use, and how
long has this fermentation technology has been around? I.e. how'd they figure it out?
A bit of a general debriefing would be nice. -- with the neat area 51 esque pictures of the early yeast reactors ECT...
Also, if anything else, can someone explain this
It says it's produced in countries "
where economic and industrial conditions favor its mass production for export.[8]"
[Edited on 2/24/2019 by Yttrium2]
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j_sum1
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How is this not a spoonfeeding request for ephedrine precursors?
This better be good or I am sending it to Detritus.
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Metacelsus
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I don't think this is necessarily spoonfeeding; Yttrium2 is just asking a biochemistry question.
Basically, pyruvate decarboxylase normally converts pyruvate into acetaldehyde + CO2 using a thiamine cofactor. However, in the presence of
benzaldehyde, the thiamine-bound intermediate can react with benzaldehyde to form L-PAC instead of releasing acetaldehyde.
edit: see this paper for more details
[Edited on 2019-2-24 by Metacelsus]
Attachment: 1-s2.0-S0922338X97819009-main.pdf (750kB)
This file has been downloaded 488 times
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Tsjerk
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Quote: Originally posted by Metacelsus  |
Basically, pyruvate decarboxylase normally converts pyruvate into acetaldehyde + CO2 using a thiamine cofactor. However, in the presence of
benzaldehyde, the thiamine-bound intermediate can react with benzaldehyde to form L-PAC instead of releasing acetaldehyde.
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As chemical synthesis of this two stereo-isomer center containing molecule probably is not economic.
[Edited on 24-2-2019 by Tsjerk]
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Waffles SS
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All possible way for synthesis (RS)Phenylacetylcarbinol
Attachment: PAC.pdf (364kB)
This file has been downloaded 991 times
Chemistry = Chem + is + Try
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Corrosive Joeseph
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Thank you for that........... But the racemate is not a desirable end product, because it kinda defeats the whole idea of this route.
/CJ
Being well adjusted to a sick society is no measure of one's mental health
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Waffles SS
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Attachment: L-PAC.pdf (404kB)
This file has been downloaded 545 times
[Edited on 24-2-2019 by Waffles SS]
Chemistry = Chem + is + Try
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