fitlaurz
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Chiral synthesis
What are the best methods when seperating racemic mixtures into the enantiomers?
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chemoleo
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Maybe you would like to work with enzymes that synthesise your compound, they are stereoselective. A lot of bioactive compounds are made this way
industrially, for the fear of one enantiomer causing havoc...
Else...crystallise, and handpick crystals with mirrored orientations... but thats gonna be tricky 
There are other ways, which I once knew, but they are not easy ... maybe someone else can help out here 
Never Stop to Begin, and Never Begin to Stop...
Tolerance is good. But not with the intolerant! (Wilhelm Busch)
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guaguanco
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| Quote: | Originally posted by chemoleo
Maybe you would like to work with enzymes that synthesise your compound, they are stereoselective. A lot of bioactive compounds are made this way
industrially, for the fear of one enantiomer causing havoc...
Else...crystallise, and handpick crystals with mirrored orientations... but thats gonna be tricky
There are other ways, which I once knew, but they are not easy ... maybe someone else can help out here |
In general, one creates a salt or simple derivative of the compound, using an optically pure chemical:
racemic amine + (-)camphorsulfonicacid -> salt
racemic alcohol + (-)camphorsulfonylchloride -> pyridine -> ester
The resulting enantiomers of the salts or molecules have different chemical properties and can often be separated with good optical purity.
some data
some other data
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