chasingit33
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what is meant by "dopaminergic tone"?
specifically the "tone" part.
never encountered that...i imagine it has to do with rate or dopamine production or something?
"Through a direct effect on anterior pituitary lactotrophs,
DA inhibits the basally high-secretory tone of the cell."
"A variety of other modulators of
prolactin secretion act at the hypothalamic level by either disinhibition of
the dopaminergic tone (e.g. serotonin, GABA, oestrogens and opioids) or
by reinforcing it (e.g. substance P)."
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chemrox
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sounds like creative writing .. maybe it means stuff that makes you feel good
"When you let the dumbasses vote you end up with populism followed by autocracy and getting back is a bitch." Plato (sort of)
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Nicodem
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It is not a stuff, it is a concept.
As far as I know, "dopaminergic tone" is more or less the same as "dopaminergic activity" or "dopaminergic transmition", all quite fuzzy concepts. For
example: an increase in dopaminergic tone in the stomach would make you puke; a decrease in the dopaminergic tone by the basal ganglia loss of
activity would cause akinesia; an increase in dopaminergic tone in the dopaminergic projections to the cortex would make you behave like an ape-like
jerk; and so on...
The point is that this concept is not specific (it says nothing about which dopaminergic transmittion system on which type of neurons, in which part
of the nervous system, has changed in modulation). But this type of concepts gained popularity, because it is something that can be measured simply
and empirically (by tracking dopamine metabolites or by monitoring secondary effects, for example).
…there is a human touch of the cultist “believer” in every theorist that he must struggle against as being
unworthy of the scientist. Some of the greatest men of science have publicly repudiated a theory which earlier they hotly defended. In this lies their
scientific temper, not in the scientific defense of the theory. - Weston La Barre (Ghost Dance, 1972)
Read the The ScienceMadness Guidelines!
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