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Author: Subject: Icaridin synthesis ?
ItalianXKem
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[*] posted on 12-2-2009 at 08:46
Icaridin synthesis ?


hi , what is the (industrial) total synthesis of molecule icaridin (picaridin) ? Is a synthetic insecticide
http://en.wikipedia.org/wiki/Icaridin
please help me




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sparkgap
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[*] posted on 12-2-2009 at 10:05


You apparently misread. :P It is an insect repellent, Autan I believe is the brand name used in Europe (but there are still DEET-containing formulations branded as Autan).

As for a synthesis, how about trying to search for the patents assigned to Bayer (now LANXESS)?

sparky (~_~)




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UnintentionalChaos
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[*] posted on 12-2-2009 at 18:26


I would imagine by treatment of the free amine with di-sec-butyl dicarbonate (analogue of t-BOC anhydride).



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sparkgap
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[*] posted on 12-2-2009 at 18:41


Actually, sec-butyl chloroformate is what they apparently use.

sparky (~_~)




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