nikotyna1939
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skatole conversion into indole
is it possible to convert skatole to indole
if you know can you show the way
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12thealchemist
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You would want to protect the nitrogen of the ring, then probably oxidise the methyl to a carboxylate group, then perform a decarboxylation, followed
by deprotection of the nitrogen. That would be my guess. You would want to pick a protecting group that would be immune to whatever oxidant you use on
the methyl.
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CuReUS
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1.Convert skatole to indole -3 carboxylic acid -https://onlinelibrary.wiley.com/doi/10.1002/cber.18880210137...
2.decarboxylate to indole by heating at 230'C -https://onlinelibrary.wiley.com/doi/abs/10.1002/cber.1897030...
its a 1 pot procedure 
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nikotyna1939
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Convert skatole to indole -3 carboxylic acid
can anybody knows the steps to Convert skatole to indole -3 carboxylic acid
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Texium
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Threads Merged
5-12-2018 at 17:27 |
UC235
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The decarboxylation is likely catalyzed by copper, since the indole should provide the essential ligand in the same way nicotinic acid does. I'd toss
in some copper chromite.
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diddi
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thats some might smelly chemistry 
Beginning construction of periodic table display
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Assured Fish
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@nikotyna1939
Im not sure if your merely posing the question for curiosity sake or if you intend on putting this to practice.
If the later is the case, where on earth did you acquire your skatole from. The stuff is hellishly expensive from most suppliers who have the balls to
sell it and i cannot imagine you made it yourself (although NileRed does have a detailed video on it).
Unless of coarse you extracted it 
Sufficiently advanced science is indistinguishable from madness.
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nikotyna1939
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nikotyna1939
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just curious
i wondered and skatole is cheaper in my country. also i needed indole for making Indole-3-butyric acid
[Edited on 9-12-2018 by nikotyna1939]
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Texium
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Thread Moved
13-3-2024 at 05:33 |
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