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Filemon
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| Quote: | Originally posted by Sandmeyer
The issue of reducing phenylalanine to amphetamine has been brought up many times here and elsewhere, to the point of becoming boring. Wetdreams is a
place to discuss repetitive, non-challenging, (meth)amphetamine-cookery topics.
[Edited on 30-12-2007 by Sandmeyer] |
It already knew WD. I don't speak as making amphetamine. I only say a way to reduce the COOH. I didn't know that method. It is certain that
nightflight wanted it to reduce the pheylalanine. I don't believe that you can apply to the phenylalanine.
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Sandmeyer
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| Quote: | Originally posted by Filemon
| Quote: | Originally posted by Sandmeyer
The issue of reducing phenylalanine to amphetamine has been brought up many times here and elsewhere, to the point of becoming boring. Wetdreams is a
place to discuss repetitive, non-challenging, (meth)amphetamine-cookery topics.
[Edited on 30-12-2007 by Sandmeyer] |
It already knew WD. I don't speak as making amphetamine. I only say a way to reduce the COOH. |
Ok, fair enough, but there are methods to reduce -COOH to -alkyl, it can be done and in high yield in couple of easy steps, i.e -COOH ---> ester
---> alcohol --SOCl2-> alkyl halide ---Pd/C--> alkane, or -COOH --B2H6--> alcohol --SOCl2--alkyl chloride ---Pd/C--> alkane...
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solo
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I may point out that alcohols halogenate better when they are HCl form and the reaction is not so difficult, even while using thionyl chloride, while
preparing peptide linking material............solo
It's better to die on your feet, than live on your knees....Emiliano Zapata.
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solo
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The reduction with a sealed vessel was attempted with a loud boom.......all was well for 40 minutes as the pressure rose to 30psi then went down to
15 psi and the reaction was left alone for what would be 6 hours .....later away from my lab I herd the loud muffled boom.......my bottle had
ruptured and all that was left was the smoldering iodine smell .....will try it again but in a metal reactor -glass lined.....that should hold back
the phosphorous attempt to blow maybe I will make sure the thickness of the reactor is 1/8 " to 1/4" thickness to withstand a good amount of
pressure........solo
[Edited on 25-2-2008 by solo]
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jon
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phosphine gas formation may i sugguest you prige your vessel next time it spontaously goes boom in contact with air. and it's formed at the
temperatures you speak of.
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ScienceSquirrel
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There are literature procedures for the preparation of amphetamine from phenylalanine.
But reduction of the naturally occuring optical isomer of phenylalanine yields the inactive isomer of amphetamine.
So you are wasting a lot of time and money making a drug that will not get you stoned!
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solo
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| Quote: | Originally posted by ScienceSquirrel
There are literature procedures for the preparation of amphetamine from phenylalanine.
But reduction of the naturally occuring optical isomer of phenylalanine yields the inactive isomer of amphetamine.
So you are wasting a lot of time and money making a drug that will not get you stoned! |
..................assuming the trial was with the (-) isomer......however the issue is not if active or not, the issue is the chemical reduction of an
acid to a hydrocarbon......yes, I've read the studies and know of Rhodiums first time published reduction of carboxylic acids to hydrocarbons, however
this is the venue of the thread to reduce the acid via a previously documented method some time ago by both Gatterman and Vogel............solo
It's better to die on your feet, than live on your knees....Emiliano Zapata.
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ScienceSquirrel
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Fair enough.
It is good for cold cures though so you can sell it on to the snuffle inhaler people if you can make it economically 
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jon
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wait a minute? so your saying d,l isomer won't yeild d,l on reduction? where did this information come from?
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Arrhenius
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Hmm.. I would think this reduction will mix up the stereochemistry, yielding probably zero ee.
[Edited on 20-8-2008 by Arrhenius]
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jon
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i.e. the chiral center remains the same unless it's"umbrellas" like in an sn2 reaction
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ScienceSquirrel
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The naturally occuring isomer of phenylalanine is L-phenylalanine and if you buy phenylalanine from a health food shop this is the one that you will
get.
D- phenylalanine is available from chemical supply houses at a price.
When you reduce the carboxylic acid group to form amphetamine there is no change in the optical centre so the natural and cheap isomer gives the
relatively inactive L isomer of amphetamine.
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nightshade
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So Solo you reduced the phenylalanine to what using I/RP?
Just kind of wondering someone called Krz said he did it years ago at the hive,but later someone said that he just made stuff up then krz went away
just like the stories he told.Right now at wetdreams they are posts that it will but I have never heard of any sucess doing direct reduction of
phenylalanine.
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nightshade
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Hello, what do you get when you reduce phenylalanine using I/RP?What I am really wondering is if can be done at all?
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solo
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| Quote: | Originally posted by nightshade
So Solo you reduced the phenylalanine to what using I/RP?
sucess doing direct reduction of phenylalanine. |
........can you point out to me where I made such claim?....as for the carboxylic acid being reduced to the alkane ....had you read the whole thread
you would have known who made the claim.....however the alcohol of phenylalanine, phenylalaninol, has been reduced to the alkane .....that claim I've
made .......next!......solo
It's better to die on your feet, than live on your knees....Emiliano Zapata.
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jon
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on the subject of the kolbe reaction it don't work here, you get dimers because the intermediates are stabilized by the lone pair on the nitrogen.
i'm retarded, but i know that much.
just so you don't waste time with that avenue.
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