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DocX
Hazard to Others
Posts: 179
Registered: 22-10-2015
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Really? Pray tell, how and when did you see this?
A warfarin overdose should most likely result in gastrointestinal bleeding. The gut of mammals has a HUGE, extremely vasculated surface area, and
bleeding disorders generally start there. To sieve blood into the gut is a pretty painless thing, you get tired, drowsy, shot of breath and faint.
Or it's a haemorrhage stroke. That can be painful, but not for long. Not like drowning.
Bleeding is sort of painless. So I really wonder what you saw?
And regarding the chemistry I have actually reached a dead end when it comes to the reagents. My hope was there would be a route with affordable and
accessible precursors, but I still haven't found one.
[Edited on 20232323/4/26 by DocX]
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Fery
International Hazard
Posts: 1026
Registered: 27-8-2019
Location: Czechoslovakia
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Reviving the thread. Did anyone succeed in 4-hydroxycoumarin synthesis?
Here I found a German page with coumarin synthesis:
http://forum.lambdasyn.org/index.php/topic,1471.0.html
I synthesized the second reactant (benzylideneacetone) here:
https://www.sciencemadness.org/whisper/viewthread.php?tid=15...
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Fery
International Hazard
Posts: 1026
Registered: 27-8-2019
Location: Czechoslovakia
Member Is Offline
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This seems to be a suitable home lab way for warfarin. But only racemic product. For obtaining stereoisomers it would be necessary to have (R,R)- or
(S,S)-1,2-diphenylethylenediamine:
https://pubs.acs.org/doi/10.1021/ed800040m
Benzalacetone synthesis is here:
https://www.sciencemadness.org/whisper/viewthread.php?tid=15...
The 4-hydroxycoumarin may be obtained from phenol and meldrum acid:
| Quote: | | Treatment of phenol with meldrum acid under solvent-free condition at 90°C afforded 3-oxo-3-phenoxypropanoic acid in 92% isolated yield, that
transformed to 4-hydroxycoumarin in 75 % and 48% isolated yield, upon treatment with Eaton’s reagent or polyphosphoric acid (PPA)
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Attachment: j.arabjc.2015.06.012.pdf (1.6MB)
This file has been downloaded 233 times
The meldrum acid may be obtained by reacting malonic acid + acetone + acetic anhydride + cat. H2SO4
Attachment: CT9089300598.pdf (244kB)
This file has been downloaded 184 times
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