Kloberth
Harmless
Posts: 38
Registered: 2-6-2023
Member Is Offline
|
|
Synthesis of CAS 3179-63-3 or 3-Dimethylaminopropan-1-ol
I am trying to make this compound for a bigger synthesis I plan to do but I just cannot find any information on the synthesis of it. Most likely I am
just not good at searching. So please help if someone can find a more detailed explanation as the one on german wikipedia:
https://de.m.wikipedia.org/wiki/3-Dimethylaminopropanol:
"3-Dimethylaminopropanol kann durch wasserfreies Kochen von Dimethylamin und Allylalkohol mit Natriumhydroxid-Flocken und anschließender wässriger
Aufarbeitung synthetisiert werden.[3] Das Produkt kann bei dieser Syntheseroute mit Benzol aus der wässrigen Reaktionslösung extrahiert werden."
"3-Dimethylaminopropanol can be synthesised by waterfree "cooking" of Dimethylamine and Allyl alcohol in sodium hydroxide. Then work up with water and
extraction with benezen."
There is also a reaction scheme which shows themperatures ao 115-120°C which is a questionmark for me. Should this be dobe under pressure??
Can someone can dig up a halfdetailed synthesis of this compount?
|
|
|
Tsjerk
International Hazard
Posts: 3032
Registered: 20-4-2005
Location: Netherlands
Member Is Offline
Mood: Mood
|
|
What bigger plan? I can imagine some bigger plan this compound could be used for, but not really one this compound is really necessary for.
|
|
|
Fery
International Hazard
Posts: 1026
Registered: 27-8-2019
Location: Czechoslovakia
Member Is Offline
|
|
https://sci-hub.ee/10.1021/ja01158a026
| Quote: | A mixture of 45 g. (1 mole) of
dimethylamine, 116.1 g. (2 mol) of allyl alcohol (Shell Chemical Co.) and 42 g. of flake sodium hydroxide (96-98%) was placed in an autoclave and
heated with agitation at 115-120' for twenty hours. The reaction mixture
was cooled to 35-40', the semi-solid mass was dissolved
in 200 cc. of water, the layers were separated and the
aqueous layer was extracted with three 50cc. portions of
benzene. The combined alcohol layer and extracts were dried over potassium carbonate and fractionated; b. p.
112-113 ' (150 mm.) and 162-163 under atmospheric
pressure, yield, 59-65% |
|
|
|
Kloberth
Harmless
Posts: 38
Registered: 2-6-2023
Member Is Offline
|
|
I am trying to synthesise an ester with this alcohol.
Finally at least some information on the synthesis, thanks.
[Edited on 30-7-2023 by Kloberth]
|
|
|
Fery
International Hazard
Posts: 1026
Registered: 27-8-2019
Location: Czechoslovakia
Member Is Offline
|
|
The info is in the link you posted (DOI).
|
|
|
Kloberth
Harmless
Posts: 38
Registered: 2-6-2023
Member Is Offline
|
|
Omg I completely forgot that wikipedia lists the sources below.
|
|
|
![[*]](images/xpblue/default_icon.gif){kind=icon}
