jarodduesing
Harmless
Posts: 12
Registered: 3-1-2022
Member Is Offline
Mood: Chaotic wonder
|
|
Multiple long synthesis doublechecks
Hello fellow chemists! I plan on placing an order for reagents soon and will be posting my finalized pathways around 1100 est. I would really
appreciate your feedback and suggestions on ways to improve them.
|
|
|
jarodduesing
Harmless
Posts: 12
Registered: 3-1-2022
Member Is Offline
Mood: Chaotic wonder
|
|
https://docs.google.com/spreadsheets/d/1BNasElQIA8ZVpZBB0JbZ...
Here is the google doc with pathways being finished.
|
|
|
karlos³
International Hazard
Posts: 1520
Registered: 10-1-2011
Location: yes!
Member Is Offline
Mood: oxazolidinic 8)
|
|
Benzodiazepines or what?
verrückt und wissenschaftlich
|
|
|
jarodduesing
Harmless
Posts: 12
Registered: 3-1-2022
Member Is Offline
Mood: Chaotic wonder
|
|
Vasopressin-1B antagonist to fix HPA axis dysfunction, out of Phase II trials for Depression but with decades of relevant research to suggest
usefulness in basically every other chronic illness, including but not limited to Chronic Fatigue, Anxiety, Panic/PTSD, IBS, and Insomnia (as well as
"Adrenal fatigue" and cognitive impairment).
|
|
|
Tsjerk
International Hazard
Posts: 3032
Registered: 20-4-2005
Location: Netherlands
Member Is Offline
Mood: Mood
|
|
Whenever a drug is claimed to fix about anything I start doubting. What is the name of the compound? I can't make sense of the spreadsheet.
|
|
|
Fery
International Hazard
Posts: 1026
Registered: 27-8-2019
Location: Czechoslovakia
Member Is Offline
|
|
jarodduesing - I'm working with psychoactive substances in my profession. I see some improvements and new compounds introduced during decades. There
were a lot of new promising substances but the most difficult part was to pass all clinical steps and even they passed we saw somewhat less
effectiveness than the producer claimed (e.g. from SNRI we completely abandoned milnacipran and duloxetine and use only venlafaxine which proven
clinically the most effective for severe depression). Some medicals which were initially registered for curing some dysfunction were later allowed to
cure more, e.g. pregabalin as anticonvulsant and against neuropathic pain was later allowed for generalized anxiety disorder. Concerning depression
some medicaments got obsolete (tricyclic antidepressant, MAO inhibitors, etc) so today I see that only newer types are used which have reduced side
effects (I saw how effective were the obsolete but also how serious side effect they had, e.g. very narrow therapeutic window so taking more than 10
pills could kill the patient, in the modern types used today patient survives even taking more 100 pills e.g. in suicidal attempt). So for depression
treatment I see currently used only SSRI, NaSSA, SNRI, NDRI and the newest one agomelatine which is somewhat much more toxic to liver than the others
and not much effective for severe depression. Anyway it would be very good if there is another kind of antidepressant. Later the compound may
eventually get registered for other disorders too if it proves its effectiveness there. I wish you and the whole team the best, the compound to be
effective and with as low side effects as possible.
So this compound is already researched for decades? Your task is to improve its synthesis? Do you have colleagues in your team which can help you or
do you hope to find someone highly skilled here (I'm not, I'm just curious) ?
|
|
|
![[*]](images/xpblue/default_icon.gif){kind=icon}
