slyder
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Possible enatioselective phenylacetylcarbinol synthesis ?
Hello,
Can someone confirm would this synthesis work in order to obtain enatioselective ( ee 99% ) R-PAC from R-mandelic acid --> Weinerb amide -->
methyl grignard ---> R-PAC ?
Thanks !
Cheers ! ![:)](./images/smilies/smile.gif)
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Texium
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It should work if you protect the alcohol first.
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slyder
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Texium thanks for reply.
Protection with sillyl group eg. tert-Butyldimethylsilyl chloride ( TBDMSCl ) or tetrahydropyranyl ether will be OK in my opionion because is the
most easiest to remove ?
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