Illegal Parkinson
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Nicotinamide => Nikethamide & Nicorandil
So i pick up a bag of nicotinamide over a year ago on ebay.
You take it as vitamin.
Then I thought to myself, this can be used to manufacture Nikethamide & Nicorandil.
However, no literature sources exist for these procedures, just general rule of thumb.
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Fery
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Nikethamide & Nicorandil are very old pharma substances, seem not to be used anymore, do you want to try to synthesize them?
You can also perform Huffman degradation of nicotinamide using hypochlorite or hypobromite to 3-aminopyridine.
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Boffis
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I think you would need to hydrolyse the amide to the free acid and convert it into the nicotinoyl chloride; no mean feat, and then condense this with
ethanolamine or diethylamine. The former would then need to be nitrated to the nitrate ester. If its possible to form nicotinoyl chloride I am sure
there will be published procedures somewhere.
3-aminopyridine undergoes Skraup's reaction like aniline to give 1,5-naphthyridine, an interesting pyridine like liqand.
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njl
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You can avoid the acid chloride by using ester aminolysis, hydrolyze -> esterify -> aminolysis with diethylamine catalyzed by acetic acid
Reflux condenser?? I barely know her!
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