shrent
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Michael addition
Hello !
I'm trying one Michael addition reaction between an acrylate based ester with l-alanine as under.
Ph-CO-CH=CH-COOC2H5 + H2N-CH(CH3)-COOH makes : Ph-CO-CH2-CH(COOC2H5)-NH-CH(CH3)-COOH.
But here, the solubility of l-alanine inhibits taking reaction in any solvent like Methanol/ethanol, etc.
Can you suggest something to perform this reaction like, solvent media, making soluble the l-alanine in any solvent & other reaction conditions ?
Regards,
shrent
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chochu3
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Registered: 21-10-2003
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These type of reactions usally need to take out water by azetropic distillation for the reaction can shift forward. Have you tried using a longer
chained alcohol (more carbons).
\"Abiding in the midst of ignorance, thinking themselves wise and learned, fools go aimlessly hither and thither, like blind led by the blind.\" -
Katha Upanishad
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