Selective cross aldol condensation for enolizable reagents
I'm looking for a selective aldol/looking to develop one. The closest I've found is linked below. I particularly want to selectively link propanal and
2-iodoethanal together.
I'm thinking an acid catalyst will significantly help for the selectivity. I'm planning on testing Al2O3, L-proline, and maybe a few other
mecondensate.
My thought is that the halo aldehyde carbonyl will be too acidic to easily enolize due to difficulties grabbing a proton or lewis acid site limiting
the undesired condensates or at least pushing the desired product towards being the major one. I would like to hear if there is something I'm missing
about the nature of aldehydes in aldol condensation. https://pubs.acs.org/doi/10.1021/ja208873k
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