kevsim
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How does enzyme phenylalanine hydroxylase generate tyrosine
I have been trying to find the following information and had no luck.
Could somebody please explain -
"How does the enzyme phenylalanine hydroxylase generate
tyrosine?"
Also could somebody please explain the following -
What general type of reactions does Ligases catalyse
kevsim
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aga
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Well, i know nothing of biochem at all, yet even I would have to ask :-
"what is phenylalanine hydroxylase generating tyrosine from ?"
and i'd probably get a clue from that.
Edit:
aren't enzyme names given by what they do ?
If so, the 'hydroxylase' part should mean something.
[Edited on 13-4-2016 by aga]
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mnick12
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Well from 5 minutes of googling it looks like hydroxylation occurs through a Fe(iv)-oxo intermediate which is formed through the cleavage of an Fe(ii)
peroxo tetrahydrobipterin intermediate.
Also Ligases, really? Just google it dude we are not doing your hw for you.
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clearly_not_atara
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Hydroxylases in the human body mostly use the same basic idea:
* forming a complex with the target molecule such that the active site is close to an iron atom
* oxidizing said iron atom with peroxide to highly reactive/unstable FeO2+ complex
* oxygen transfer from FeO2+ to the substrate.
The FeO2+ complexes can be generated in vitro very transiently, but modern science has no molecular machinery with which to transport this
species to the desired hydroxylation site.
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phlogiston
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ligases connect two molecules together. Probably the most well known ligases are DNA ligases that connect two strands of DNA together and are commonly
used as a tool in molecular biological labs.
If we do your homework, will you please promise to just become a mailman or garbage collector, so the rest of us that is willing to make some effort
can have the nice jobs and houses with a garage large enough to put our mad scientist lab in?
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"If a rocket goes up, who cares where it comes down, that's not my concern said Wernher von Braun" - Tom Lehrer |
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kevsim
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I thank you all for the replies.
kevsim
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