Aqua-regia
Hazard to Others
Posts: 136
Registered: 18-12-2006
Member Is Offline
Mood: No Mood
|
|
2,6-dichlororo pyridine 4 carboxilic acid reduction to isonicotinic acid
I am looking to synthesize isonicotinic acid from citrazinic acid. The route to get 2,6-dichloro-pyridine-4 carboxilic acid was easy, but the
reduction of halogen need a cheap procedure. (no hydrazine and LiAlH) A little bit of preliminary googling I found this:
What is your opinion about this things
Attachment: php6AuIoN (32kB) This file has been downloaded 790 times
|
|
Weinreb
Harmless
Posts: 8
Registered: 13-1-2014
Member Is Offline
Mood: No Mood
|
|
I have performed the Mg/isopropyl alcohol reduction on chlorobenzene, yield was excellent on this substrate. The magnesium was standard turnings used
for Grignard reactions.
|
|
Aqua-regia
Hazard to Others
Posts: 136
Registered: 18-12-2006
Member Is Offline
Mood: No Mood
|
|
Thank you, its sounds good. I hope that the pyridine ring don't occurse barrier, or formed dipyridine bond and no spherical inhibition.
|
|
Dr.Bob
International Hazard
Posts: 2782
Registered: 26-1-2011
Location: USA - NC
Member Is Offline
Mood: Mildly disgruntled scientist
|
|
Quote: Originally posted by Aqua-regia | Thank you, its sounds good. I hope that the pyridine ring don't occurse barrier, or formed dipyridine bond and no spherical inhibition.
|
Huh?
|
|