hmtlion
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3',4',5'-trichloro-2,2,2-trifluoroacetophenone
Dear All
I wish to make 3',4',5'-trichloro-2,2,2-trifluoroacetophenone for my research work.
did any one made this compound?
Please provide all information
Regards
Hardik
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kavu
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This patent describes one possible synthesis: WO2012120135
They lithanate 5-bromo-1,2,3-trichlorobenzene and toss in ethyl trifluoroacetate.
[Edited on 4-1-2013 by kavu]
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kristofvagyok
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Quote: Originally posted by kavu  | This patent describes one possible synthesis: WO2012120135
They lithanate 5-bromo-1,2,3-trichlorobenzene and toss in ethyl trifluoroacetate. |
Important to note for that they used some n-BuLi for the metallation of the trichlorobromobenzene what is not the best to work with.
I would suggest to use a Grignard instead of the BuLi, much better to work with...
If 3,4,5 trichlorobenzaldehyde is aviable than there is also another route, with trifluormethyl-iodide or bromide, a schlenk tube and some zinc
powder. It will form the corresponding alcohol what could be easily oxidized to the ketone.
This is described at: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 7 p. 1951 -
1957
Another version: Chemistry Letters, 1984 , p. 517 - 520
Also there is another version of this reaction where they generate the trifluormethyliodide in situ from sodium trifluoracetate: Journal of Fluorine
Chemistry, 2005 , vol. 126, # 6 p. 937 - 940
I have a blog where I post my pictures from my work: http://labphoto.tumblr.com/
-Pictures from chemistry, check it out(:
"You can’t become a chemist and expect to live forever." |
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hmtlion
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Thanks
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VitaminX
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I synthesized 2',2',2'-Trichloro and 2',2',2'-Trifluoroacetophenone (without ring substitution) and I have to warn you. It is a VERY strong
lachrimatory. I wanted to die right there right now.
It was synthed from acetophenone with Cl2 gas. Synthesis was performed from: Cohen S., Wolosinski H., Scheurer P., J. Am. Chem. Soc., 72, 3952,1950
If you start from the 3,4,5-trichloroacetophenone you should get what you need.
[Edited on 11-1-2013 by VitaminX]
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hmtlion
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Thnaks
Thnaks, I got the compound. via grignard
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aliana
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did any one made this compound?
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