DeusExMachina
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Paralyzing Substance
For those of you that watch discovery channel (not madscientist: D) you'll know what I'm talking about. If you've seen on TV people in the jungle with
blow pipes and blow out darts and shoot animals, the animal that gets shot gets poisoned or paralyzed. Does anyone know what the subtance that is most
commonly used for this is called? Maybe provide a link to some information about it? I've searched and found nothing.
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Rhadon
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Curare and strychnin (alkaloids) are used for that purpose.
In general, you could use any poison which is potent enough and fast enough, but not all of them will paralyze the victim before killing him.
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DeusExMachina
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ya, I know that not all of them will paralyze the animal first. I was just trying to make it easier for people to understand. Thanks for your help
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DeusExMachina
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http://www.botanical.com/botanical/mgmh/n/nuxvom08.html
thats something for curare (it has a different name but when I searched it, it told me to go to this page for it
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PHILOU Zrealone
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A lot of quaternary ammonium hydroxydes have paralysing effect!
NH4OH< Et4NOH < Me4NOH < Iprop4NOH < (CH3-CO-CH2)4NOH = (CH2=CH-CH2)4NOH
You may conclude that:
(Ar-CH2)4NOH will also be a strong one
The (CH2=CH-CH2)4NOH is found to be the major ingredient of anemon toxin to paralyse fishes!
PH Z (PHILOU Zrealone)
"Physic is all what never works; Chemistry is all what stinks and explodes!"-"Life that deadly disease, sexually transmitted."(W.Allen)
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unionised
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That web page is about strychnos which gives rise to strychnine, a convulsant poison. Curare comes from a different plant (chondodendron tormentosum)
and causes death by relaxing the muscles.
Strychnine is not a quaternary ammonium compound but curare, or rather tubocurarine, is. For a long time it was thought to have 2 quaternary groups in
the molecule. This spawned a theory about its mode of action which, in turn, gave rise to some useful drugs. In fact, it turns out that they were
mistaken, but the drugs are still used.
On the subject of quaternary amines, ammonium hydroxide can barely be said to exist. The 2 quaternary ammonium ions, cholinium and N-methyl atropinium
have opposite effects on the nervous system.
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PHILOU Zrealone
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Despite its barely existence...NH3.H2O when injected in the body has real toxic effects...which besides burns are catatony...
It is one of the more accessible toxic stuff.
When I said a lot of ammonium quaternary...it of course implicitely means there are exceptions...but the ones I have written are indeed true
paralysants.
Quite easy to synthetise for average organo chemist.
PH Z (PHILOU Zrealone)
"Physic is all what never works; Chemistry is all what stinks and explodes!"-"Life that deadly disease, sexually transmitted."(W.Allen)
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hornek
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paralyzing effect
As I know, the paralyzing staff using in zoo's for paralyzing animals is nicotin acid.
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unionised
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Could you elaborate on that a bit please?
The last I heard was that they used potent opiates to tranquilise animals in zoos.
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Nevermore
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| Quote: | Originally posted by hornek
As I know, the paralyzing staff using in zoo's for paralyzing animals is nicotin acid. |
sound strange at me, nicotinic acid should be toxic and now really show paralyzing effects at low (non lethal) doses..
Nevermore!
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gil
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frogs,deus gratia.Frogs.
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Sauron
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The active compound in curare is d-tubocurarine, q.v.
strychnine and brucine are alkaloids from Nux vomica.
A modern arrow poison used by bow hunters against medium game is succinylcholine. Also used in anaesthesia.
You will certainly want to look into the physiological role of choline in neurotransmission if you want to understand the toxic action of quaternary
ammonium salts.
Get a good text on anaesthesia and you will learn a lot. Any anaesthatist will tell you, there are 100 steps from consciousness to death and in
general anaesthesia you are brought to somewhere in the last 5 steps. You understand ED50 vs LD50? Normally in pharmacology the effective does is
lower than the lethal dose. But in the case of anaesthetics the reverse is true. Scary stuff.
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Sauron
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You might also want to look into tetradotoxin, the toxic principle of the puffer fish (Japanese fugu) used by ninja assassins for centuries. As fugu
is a delicacy in Japanese cuisine, chefs who prepare fugu are specially trained and licensed. Accidents still happen. Abbreviation TTX
The same toxin is one of the main ingredients in zombi dust in Haiti.
We also might mention saxitoxin and related substances from the red-tide dinoflagellates.
And the bufotoxins from various species of tree frog.
But you really ought to get up to speed on physiological chemistry and biochem in order to grasp the mechanisms by which these operate.
[Edited on 16-1-2007 by Sauron]
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gil
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In fact,talkin about it,long time ago i had a total anesthesia,surgery right knee.At final stages I regained
cosciusness,I mean fully awake, coul hear... That's it:I couldn't move a finger,or open my eyes,I couldn't
take a breath in or make a noise.But my brain was fully awake,as I'm now.How long for,Hard to tell.Panic set in,then I felt the pressure from the
oxigen mask on my face,the flow of air filling my lungs and relaxed a bit,knowing I was looked after,but still totally paralized,incapable to breath,I
remember clearly a second
oxigen intake then I must have passed out again.I woke up in bed.Scary!Scary one.
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Sauron
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A little scop would have had you less aware of your situation.
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gil
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Whath? Scopolamina?Or scopolamilva?Or scopolavanoni?
Ithappened at the end, when patient get revived. 30 or 60 seconds the most. Hard to say
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YT2095
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tetradotoxin is another IIRC.
edit: sorry, I didn`t see someone already mentioned it 1`st time around..
[Edited on 15-1-2007 by YT2095]
although to make this post worth it, clostridium botulin toxin also works (botox).
[Edited on 15-1-2007 by YT2095]
\"In a world full of wonders mankind has managed to invent boredom\" - Death
Twinkies don\'t have a shelf life. They have a half-life! -Caine (a friend of mine)
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Misanthropy
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The -onium compounds. Not sure if that's what Phillou was referring to...
~50mg Dantrolene leaves one quite unable to move over the weekend! 
http://en.wikipedia.org/wiki/Dantrolene
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Sauron
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Such as hemicholinium-3 for example?
A specialized acetylcholinesterase inhibitor
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gil
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| Quote: | Originally posted by Misanthrop
~50mg Dantrolene leaves one quite unable to move over the weekend! :p
Better a good session whith 2-cleavaged-(nonconiugated)-Bicycled Buttanone(mettil-penein-Ether Esther) strontium Culactone!
Done properly over W.end would leave not paralized butQuite in a state!Specially if There's low tolerance to the stuff! Gettin' rare lately!
[Edited on 16-1-2007 by gil] |
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