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Author: Subject: Amides from urea
biomechem
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[*] posted on 7-1-2018 at 12:36
Amides from urea


Is is possible to obtain every amide in the way acetamide is prepared from acetic acid and urea? I know other routes like bubbling ammonia gas to acids for a few hours, but if the reaction with urea proceeds I would prefer to choose this. I am interested in:
1. butanoic acid
2. stearic acid

According to the firs one I see no problems because both acetamide and butyramide have similar b.p.. Can somebody assure me if it works?

Stearic acid has high boiling point, but it melts in 72 C so there should be no problems too.

On a Doug's Lab channel he heated the mixture to ~140C, but can you tell me if heating above 150C, and the resulting formation of biuret will affect the reaction?

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