Magpie
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1,3 propanediol
This "green" reagent is now available OTC. I knew that it eventually would be, but it took several years.
http://www.makingcosmetics.com/Propanediol-13_p_1064.html
The single most important condition for a successful synthesis is good mixing - Nicodem
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Aqua-regia
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Thss stuff is made in Dupont Tate&Lyle i guess. You can request 1 liter sample. I did it, was OK.
http://www.duponttateandlyle.com/susterra
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Velzee
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I still haven't found a use for the chemical, due to my lack of knowledge and equipment...
Check out the ScienceMadness Wiki: http://www.sciencemadness.org/smwiki/index.php/Main_Page
"All truth passes through three stages. First, it is ridiculed. Second, it is violently opposed. Third, it is accepted as being self-evident."
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Aqua-regia
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This stuff is very good starting material for building.
For example, if I synthetised first piperidine, the pathway was following:
Started with 1,3propandiol, than
-1,3 dibromo-propane after that
- glutaronitrile, and
-cadaverine HCl
finally cyclysation to piperidine.
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unionised
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Just waiting for the first arrest based on oxidation, esterification, alkylation and reaction with urea.
[Edited on 2-11-15 by unionised]
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UC235
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The most valuable use of the material is probably the oxidation to malonic acid (Which Magpie has demonstrated using nitric acid), which is used (as
the diester) in the malonic ester synthesis and can be used for Knoevenagel condensations.
Malonate ester condenses with ureas to give Barbituic acid derivatives. Plain barbituic acid can be oxidized with nitric acid to alloxan per orgsyn
which is used as a TLC visualizing agent for certain amines and notably amino acids.
Malonic acid is used in the Briggs–Rauscher and Belousov–Zhabotinsky oscillating reactions.
Conc H2SO4 and HBr converts the diol to 1,3-dibromopropane which has some niche synthetic uses as an alkylating agent and can be made into
cyclopropane by intramolecular Wurtz coupling.
The diol can also be used to make acetals and ketals as protecting groups that are easier to remove than the related ethylene-glycol derived
dioxolanes.
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gdflp
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Or partial bromination, followed by reaction with magnesium, CO<sub>2</sub> and acidic workup.
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Velzee
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Quote: Originally posted by unionised  | Just waiting for the first arrest based on oxidation, esterification, alkylation and reaction with urea.
[Edited on 2-11-15 by unionised] |
Is this a synthesis of some sort of illegal drug? Pardon my ignorance, but could you elaborate on why you stated "arrest?"
Check out the ScienceMadness Wiki: http://www.sciencemadness.org/smwiki/index.php/Main_Page
"All truth passes through three stages. First, it is ridiculed. Second, it is violently opposed. Third, it is accepted as being self-evident."
—Arthur Schopenhauer
"¡Vivá Cristo Rey!"
—Saint José Sánchez del Río |
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gdflp
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| Quote: Originally posted by Velzee | | Quote: Originally posted by unionised | Just waiting for the first arrest based on oxidation, esterification, alkylation and reaction with urea.
[Edited on 2-11-15 by unionised] |
Is this a synthesis of some sort of illegal drug? Pardon my ignorance, but could you elaborate on why you stated "arrest?" |
That's a general synthesis for barbiturates.
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Velzee
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Ah. Thank you for the clarification.
Check out the ScienceMadness Wiki: http://www.sciencemadness.org/smwiki/index.php/Main_Page
"All truth passes through three stages. First, it is ridiculed. Second, it is violently opposed. Third, it is accepted as being self-evident."
—Arthur Schopenhauer
"¡Vivá Cristo Rey!"
—Saint José Sánchez del Río |
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jamit
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Thanks Magpie. I just order a 500ml bottle. Atlas, i can make malonic acid.
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unionised
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It's a grave problem when young people forget to use protection.
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UC235
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That was hilarious.
Also, the proposed reaction is the most ridiculous approach to GHB I've ever seen.
Also, I ran across this cool prep which could use the diol two different ways to make a cyclobutane derivative. http://www.orgsyn.org/Content/pdfs/procedures/CV4P0288.pdf
[Edited on 7-11-2015 by UC235]
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gdflp
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Har har har, I walked into that one.
I didn't realize that jokingly suggested synthetic schemes had to be high yielding, use cheap reagents, and be easily performed
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unionised
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| Quote: Originally posted by gdflp |
I didn't realize that jokingly suggested synthetic schemes had to be high yielding, use cheap reagents, and be easily performed |
No, they merely have to work.
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jamit
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I just received my 500ml bottle of 1,3 propanediol. Yay!! Thanks Magpie.
Now it's time to make some malonic acid. I can't understand why this acid is so expensive!? But now that I have 1,3 propanediol, I can make it
anytime when I need it. I love sciencemadness!!
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mr.crow
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Thanks for the link. DuPont never sent me the free sample.
Also of note on the website:
- BHT
- Cetrimonium chloride (phase transfer catalyst!)
- EDTA
- Salicylic acid
- Niacinamide
Double, double toil and trouble; Fire burn, and caldron bubble
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