Bonee
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Friedel-crafts acylation temperature question
Is there any rationale lowering the temperature of a FC acylation to -70?
and doing it in a dry ice/acetone bath?
most preps are doing it at 0, but then other people use -70...
I couldn't find anything about it on the net or in books...
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Chemosynthesis
International Hazard
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Is there a noticeable difference in reaction scale between the two temperatures?
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Bonee
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no, not really, that's why i am curious
true that it may be easier to control a bigger batch with lower temperatures.
but is there any literature involving increased yield, or anything else?
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Nicodem
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Thread Moved
3-3-2014 at 13:22 |
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