AttiganDruga
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Registered: 16-5-2012
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OK to Use denatured alcohol for reductive amination reaction?
Does using an alcohol other than ethanol do anything to harm the reaction? Methanol for example or the small amount of denaturant? 190 proof vodka is
expensive, denatured alcohol from the hardware store is less expensive. Thanks.
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zed
International Hazard
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Registered: 6-9-2008
Location: Great State of Jefferson, City of Portland
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Some reductive aminations are run in methanol. Another popular solvent is Isopropyl Alcohol. Cheap, untaxed, easy to obtain, fairly safe to use.
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chemrox
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if the reaction generates water I would want an immiscible solvent like toluene that boild above water so I can use a Dean Stark. Alcohol might work
with sieves
"When you let the dumbasses vote you end up with populism followed by autocracy and getting back is a bitch." Plato (sort of)
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