Synthesis of phenylpiracetam from phenibut
Hello there, for some time (quite long) I'm searching the internet for synthesis of phenylpiracetam and what caught my attention is thing i saw on
wikipedia:
"Phenylpiracetam is readily-synthesized commercially. To avoid the problem of attaching the phenyl group to piracetam at position 5 rather than 3 or
4, commercial syntheses cyclizes phenibut by replacing the hydroxide with a hydrogen to create a pyrrole group and then reacting bromoacetic acid and
ammonia to replace the bromine with the nitrogen on the pyrrole. This produces a racemic phenylpiracetam, which then undergoes purification to produce
the final product."
I have also seen other members struggling with synthesis of phenylpiracetam and this seems to be the answer.
But unfortunately I couldn't find any further informations about that process.
How to do this cyclisation of phenibut and how would whole process look like?
Maybe somebody there is familiar with these types of reactions and can help me? It seems very promising as phenibut is readily available and quite
cheap, but phenylpiracetam is not that cheap yet.
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