zephler
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important! piperidone with two -OH vs. the preferred =O one
Ok, so a friend is trying to buy 4-piperidone (I always thought it was 4-piperidinone) from some chinese supplier, but all they have is the one (oddly
with the exact same CAS#) with two hydroxy groups instead of the =O ketone functionality. They claim, that if they remove a water, then it produces
the desired molecule with the ketone functionality, and that this molecule is unstable, and will eventually break back down into the di-hydroxy
molecule. My fear is that in them saying they are removing water, is just that they will remove the water of crystalization? Can anyone PLEASE
comment on the change from piperidone with two OH groups to piperidone with a ketone functionality?
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undead_alchemist
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It could also be why it is sold many times as a HCl salt.
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garage chemist
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Free 4-piperidone is unstable and undergoes self-condensation.
Buy the hydrochloride.
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zephler
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why is it that 4-piperidone with a ketone functionality
why is it that most people sell what they call 4-piperidone hcL monohydrate that has a diol functionality and instead of the ketone functionality?
According to sigma, both the one with the diol group and the one with a ketone have the same CAS number? Can the diol be reacted into the much more
useful ketone ? How?
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garage chemist
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Perhaps it's the same situation as with chloral hydrate and Ninhydrin, that the geminal diol is more stable and the carbonyl compound is not an
article of commerce.
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Nicodem
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Threads Merged
23-12-2010 at 07:42 |
Nicodem
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Thread Moved
23-12-2010 at 07:43 |
k2976
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It's because it's the monohydrate, forms the unstable carbonyl with removal. Once it's the freebase it's gone. You should really know that before you
ever thought about ordering this compound. This chemical is very closely watched as a precursor to fentanyl so you better have a
ACTUAL company when customs takes it and forwards it to the DEA for delivery (literally has happened to people I talk to). If
it was that easy wouldn't everybody be doing it? Use common sense or go to jail.
[Edited on 26-12-2010 by k2976]
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MagicJigPipe
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Yes, if he actually ordered this he WILL be going to jail. Although it would be interesting to see something fall through the cracks.
"There must be no barriers to freedom of inquiry ... There is no place for dogma in science. The scientist is free, and must be free to ask any
question, to doubt any assertion, to seek for any evidence, to correct any errors. ... We know that the only way to avoid error is to detect it and
that the only way to detect it is to be free to inquire. And we know that as long as men are free to ask what they must, free to say what they think,
free to think what they will, freedom can never be lost, and science can never regress." -J. Robert Oppenheimer
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