mackolol
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Methylation of 5-htp to melatonin
Hi, I'm wondering if one could methylate 5htp to melatonin using for example methyl iodide, would it work, and how should it be done? I can't find any
informations about it in internet. Also wouldn't it methylate also amide group?
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zed
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https://en.wikipedia.org/wiki/Melatonin
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karlos³
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What zed wants to say is, 5-HTP is an amino acid, and melatonin is an acetylamide.
You can surely turn 5-HTP into 5-methoxytryptophan, decarboxylate that and acetylate the amine to get melatonin.
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mackolol
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Oh sorry, my bad I thought that melatonin is methoxy tryptophan. So how would I methylate that stuff just to methoxy tryptophan?
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karlos³
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Probably like you would methylate a phenol too.
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