acorks
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Synthesis cis-3-Aminocyclobutanecarboxylic acid(CAS#:74316-27-1)
I have synthesized 3-Oxocyclobutanecarboxylic acid (CAS#:23761-23-1), Who can give some suggestions about synthesizing
cis-3-Aminocyclobutanecarboxylic acid(CAS#:74316-27-1)?
Thanks in advance!
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Sedit
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This is an amature chemistry forum. If you would like help on you profit making ventures perhaps it would be wise to give a little back such as doing
a writeup on your synthesis of Oxo-cyclo-butanecarboxylic acid and see where it goes from there. Im sure you would get a MUCH warmer welcome here.
Knowledge is useless to useless people...
"I see a lot of patterns in our behavior as a nation that parallel a lot of other historical processes. The fall of Rome, the fall of Germany — the
fall of the ruling country, the people who think they can do whatever they want without anybody else's consent. I've seen this story
before."~Maynard James Keenan
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Nicodem
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Thread Moved
23-9-2009 at 04:46 |
Arrhenius
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My consultations start at $75 an hour. Reductively aminate with sodium acetate and sodium cyanoborohydride, or form the Schiff base from benzylamine,
reduce and de-benzylate. Isolate the cis- meso compound. Alternatively: esterify, reduce to the cis-alcohol with K-selectride, chlorinate with
thionyl chloride in pyridine to give trans-chlorine, then aminate (gabriel, diphenylmethylamine, benzylamine, etc.) to give cis-amino group.
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